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Levodopa (LD) remains the gold standard for treating Parkinson’s disease (PD), but its short half-life (about 60-90 minutes) and narrow absorption window in the upper small intestine present major challenges. Standard immediate-release (IR) tablets cause fluctuating LD levels in the blood, leading to “Off” episodes (when medication isn’t working) and dyskinesia (involuntary movements).
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CREXONT (also known as IPX203) is a next-generation oral ER formulation that is quickly becoming the reference standard in many markets. It is designed with two key features in a single capsule: for rapid onset of action (similar to IR tablets) and extended-release pellets incorporating a mucoadhesive polymer that helps keep the drug in the small intestine for longer-lasting efficacy.
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